Round two of the Aviva Premiership campaign is rounded off on Sunday as Gloucester travel to the Allianz Park to face Saracens.
Sarries were the biggest scorers of the first round as Chris Ashton and Billy Vunipola touched down either side of a Jamie George brace to register a bonus-point victory over London Irish.
British and Irish Lions stand-off Owen Farrell produced a peerless kicking display as he dissected the uprights eight times to add 22 points taking the tally to 42-20.
It was less than enjoyable for Gloucester however as they left their comeback too late, eventually falling six short against Sale Sharks.
Nigel Davies' men made a valiant effort in the final half an hour to come from 19-3 down to 22-16, earning a losing bonus point to get them off the mark.
Saracens show a solitary change fresh from their flying start as centre Duncan Taylor takes over from England international Brad Barritt.
Wales international scrum-half Tavis Knoyle will makes his full Premiership debut for Gloucester at the expense of Dan Robson.
A reshuffled back-row sees blindside flanker Sione Kalamafoni move to number eight instead of Ben Morgan, with Matt Kvesic wearing the number six jersey and Akapusi Qera starting at openside.
There was nothing to choose between the pair in the previous campaign with each registering a 28-23 victory at the respective home grounds.