The third round of the Aviva Premiership starts on Friday night with two fixtures; Worcester host Harlequins and Sale entertain Wasps.
Worcester flanker Jake Abbott will make his first start of the season in a side containing four changes, all in the pack.
Jeremy Becasseau and John Andress form an all-new prop combination, while Dean Schofield is recalled at lock.
Abbott's inclusion on the openside means there is a positional reshuffle in the back row; skipper Jonathan Thomas moving to No.8 and Sam Betty onto the blindside.
Harlequins have Jordan Turner-Hall, Paul Doran Jones, Joe Gray, Charlie Matthews, Nick Kennedy, Sam Twomey, Ross Chisholm and Ollie Lindsay Hague in the treatment room.
Turner-Hall is seeing a specialist over a hip problem that may require surgery, Jones should only be out for a week with a knock sustained against Saints, but Gray is sidelined for two months because of a knee problem.
Myall faces former employers
Wasps, on a losing run of 10 matches in all competitions dating back to February, have handed league debuts to Kearnan Myall and Carlo Festuccia for the trip to AJ Bell Stadium.
Ex-Sale player Myall has overcome an ankle injury and replaces Tom Palmer, who has an arm injury, in the second row among four changes to Wasps' starting XV.
Scrum-half Charlie Davies and centre Ben Jacobs get their chance after impressing off the bench during the 30-26 defeat at Exeter, while Italy international hooker Festuccia is preferred to Tom Lindsay.
Stand-off Danny Cipriani is included in Sale's match-day squad for the first time this season.
Cipriani makes the bench, while Ross Harrison, Tommy Taylor, Kirill Kulemin and Robert Miller all come into the starting XV.