Harlequins have confirmed that forwards Olly Kohn and Will Skinner have been forced to retire due to injury.
Kohn struggled with injury throughout last season and after undergoing exploratory should surgery, doctors found the injury to be more severe than initially thought. The surgeon recommended the 32-year-old should hang up his boots immediately.
Meanwhile, Skinner has not played for Quins for more than a year and despite the best efforts of the player alongside club's medical staff, the 29-year-old has been advised to call it quits.
The duo were part of Harlequins' Challenge Cup winning side in 2011 as well as the Aviva Premiership squad crowned champions in 2012.
Both players joined the London club in the summer of 2006, Kohn from Bristol and Skinner from Leicester.
Welshman Kohn went on to make 139 appearances for the club, scoring four tries and also made his international debut earlier this year, whilst contracted to Quins.
Skinner has represented England at both U17 and U19 level as well as playing for England Saxons, becoming captain in 2008.
The flanker also captained Quins during the 2008-09 and 2009-10 seasons, making a total of 149 appearances for the club before injury intervened.
Skinner confirmed his disappointment at having to quit the sport but hopes to maintain his ties to Harlequins.
"I'm sorry to have had to call it a day as a player. Every player is devastated when the decision to retire is taken out of his hands but I hope to maintain my strong relationship with the game and with Harlequins," he said.
Kohn, whose retirement has perhaps come as more of a shock that Skinner's, was philosophic about being forced to stop playing.
"I'm disappointed to have to retire as I thought I had a few more seasons to go," he said. " I will look back at my time in rugby, especially at Quins with many fond memories.
"I feel very lucky to have been part of a fantastic club with a great set of players and coaches that have helped me achieve some massive highs in my career."