Remi Tales has withdrawn from the France squad to face England in the opening match of the Six Nations.
The fly-half has lost his battle to recover from an arm injury in time to take on England at the Stade de France next Saturday.
Tales sustained the biceps injury playing for Castres against Leinster in the Heineken Cup a fortnight ago, and he will continue to have treatment on the problem over the next week.
France coach Philippe Saint-Andre confirmed that Francois Trinh-Duc has been called up to replace Tales, who he hopes will be fit to feature at some point in the tournament.
"Francois Trinh-Duc is back with us. Remi will heal and we hope he will be back on the turf very soon," Saint-Andre said in a statement.
Montpellier's Trinh-Duc has not featured for his country since the Six Nations victory over Scotland last year.
Trinh-Duc will compete for the No 10 jersey with Jules Plisson and Jean-Marc Doussain, while The French Rugby Federation confirmed that Jean-Marcellin Buttin will also play no part in the Paris showdown.
The full-back suffered an injury playing for Clermont in Saturday's Top 14 defeat to Bayonne, and the FFR announced that Marc Andreu has taken his place in the squad.
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