Castres prop Yannick Forestier has been handed his France debut and flanker Yannick Nyanga returns after a five-year absence in Saturday's Test with Australia in Paris.
The French, who will have Frederic Michalak pulling the strings at fly-half, will be looking for their first win over the Wallabies since a 26-16 win in Marseilles in November 2005.
Forestier is given his first France cap at the age of 30 and Toulouse stalwart Nyanaga is named in the back row for the first time since 2007 in what is otherwise a familiar Les Blues pack.
He will play on the blindside in place of skipper Thierry Dusautoir, who is ruled out through injury - lock Pascal Pape takes the armband.
Jocelino Suta, the rising Toulon star, will make his France debut if he comes off the bench.
Two players who made their debuts in Argentina, Castres full-back Brice Dulin and Racing Metro scrum-half Maxime Machenaud, are given another chance to impress along with Michalak, who looked back to his best on the summer tour.
Clermont star Morgan Parra starts on the bench after missing a few days of training with an injury.
Coach Phillipe Saint-Andre said: "The selections follow the logic of the last Test in Argentina when we were happy with Maxime Machenaud and Frederic Michalak.
"The choice was also made more simple by the fact that Morgan has only been able to train for three days."
France: 15 Brice Dulin, 14 Wesley Fofana, 13 Florian Fritz, 12 Maxime Mermoz, 11 Vincent Clerc, 10 Frederic Michalak, 9 Maxime Machenaud, 1 Yannick Forestier, 2 Dimitri Szarzewski, 3 Nicolas Mas, 4 Pascal Pape, 5 Yoann Maestri, 6 Yannick Nyanga, 7 Fulgence Ouedraogo, 8 Louis Picamoles
Replacements: 16 Benjamin Kayser, 17 Thomas Domingo, 18 Vincent Debaty, 19 Jocelino Suta, 20 Damien Chouly, 21 Morgan Parra, 22 Francois Trinh-Duc, 23 Yoann Huget