Brice Dulin and Yvan Watremez will make their international debuts when France take on Argentina in Cordoba on Saturday.
Castres-bound Dulin has been handed the No.15 shirt, while Biarritz prop Yvan Watremez comes into the front row.
Yoann Huget and Fulgence Ouedraogo also come into the France line-up, while coach Philippe Saint-Andre has also named three more uncapped players on the bench.
Toulouse's teenage hooker Christopher Tolofua, Perpignan lock Romain Taofifenua and Agen scrum-half Maxime Machenaud will all make their debuts if used.
With Thierry Dusautoir rested Pascal Pape will skipper Les Bleus.
France: 15 Brice Dulin, 14 Jean Marcellin Buttin, 13 Wesley Fofana, 12 Florian Fritz, 11 Yoann Huget , 10 Francois Trinh Duc, 9 Morgan Parra , 8 Louis Picamoles, 7 Fulgence Ouedraogo, 6 Wenceslas Lauret, 5 Yoan Maestri, 4 Pascal Pape (c), 3 David Attoub, 2 Dimitri Szarzewski, 1 Yvan Watremez.
Replacements: 16 Christopher Tolofua, 17 Vincent Debaty, 18 Romain Taofifenua, 19 Alexandre Lapandry, 20 Maxime Machenaud, 21 Frederic Michalak, 22 Maxime Mermoz.