Argentina coach Santiago Phelan has made eight changes to his line-up for the first Test clash with France in Cordoba.
The Pumas warmed up for their forthcoming inclusion in the inaugural Rugby Championship with a 37-22 win over Italy and they will look to build on that against Les Bleus.
Six of the switches have come in the pack with a new-look front-row of Eusebio Guinazu, Bruno Postiglioni and Nahuel Tetaz Chaparro joined by Edinburgh lock Esteban Lozada and flankers Julio Farias Cabello and Tomas De la Vega.
The inclusion of De la Vega at openside means that Tomas Leonardi moves to No.8.
In the backs, there are call-ups for Roman Miralles and Manuel Montero. Miralles will start at full-back with Joaquin Tuculet moving to centre and Belisario Agulla joining Montero on the wing.
Phelan has also opted to rotate his squad on the bench with Andres Bordoy, Pablo Henn, Rodrigo Bruno, Rodrigo Baez, Benjamin Urdapilleta and Facundo Barrea having not played any part in the win over the Azzurri.
Argentina: 15 Roman Miralles, 14 Belisario Agulla, 13 Joaquin Tuculet, 12 Felipe Contepomi (captain), 11 Manuel Montero, 10 Ignacio Mieres, 9 Martin Landajo, 1 Eusebio Guinazu, 2 Bruno Postiglioni, 3 Nahuel Tetaz Chaparro, 4 Benjamin Macome, 5 Esteban Lozada, 6 Julio Farias Cabello, 7 Tomas De la Vega, 8 Tomas Leonardi
Replacements: 16 Andres Bordoy, 17 Pablo Henn, 18 Rodrigo Bruno, 19 Rodrigo Baez, 20 Tomas Cubelli, 21 Benjamin Urdapilleta, 22 Facundo Barrea.