Wales full-back Leigh Halfpenny will miss the rest of the season after dislocating his right shoulder during the 29-18 Six Nations defeat to England.
Halfpenny kicked all Wales' points at Twickenham with six penalties but was forced out of the action with four minutes remaining.
He appeared to suffer the injury when he tackled England centre Luther Burrell.
Burrell would have scored his second try of the game, but his foot hit the touchline in the process of touching down.
Wales head coach Warren Gatland revealed in his post-match press conference the extent of Halfpenny's injury.
"Leigh has dislocated his shoulder," Gatland said. "That will be Leigh's season over, which is disappointing for him."
The injury also means Halfpenny, 25, has played his last game for Cardiff Blues as he has signed for French side Toulon on a two-year contract from next season.
Scarlets back Liam Williams will be favourite to replace Halfpenny in next Saturday's final Six Nations game against Scotland in Cardiff after coming on for him at Twickenham.
Scrum-half Rhys Webb also went off injured, suffering what appeared to be an ankle injury, but there was no immediate fitness update on him.