Wales captain Sam Warburton admitted to a 'massive feeling of frustration' after his side went down to a 24-15 defeat against South Africa at the Millennium Stadium.
Wales were competitive throughout a closely-fought contest, but could not match the Springboks' cutting edge.
Tries from Jean de Villiers, Bismarck du Plessis and Fourie du Preez, seven points from Morne Steyn and a conversion from Pat Lambie were enough to see off the Six Nations champions.
Wales, who were hit by first-half injuries to Jonathan Davies, Liam Williams, Adam Jones and Scott Andrews, registered five penalties from Leigh Halfpenny but it was not enough.
Asked about how he felt about the defeat, Warburton said: "A massive amount of frustration.
"We had genuine belief we could have won this weekend but it wasn't to be."
He added: "We were in control for 23 minutes of the second half.
"It seems against these top sides you make one mistake and pay the price.
"But South Africa are a top-quality side. They finished their chances when they had to."
Meanwhile, there was more bad news for Wales when it was confirmed by head coach Warren Gatland that centre Jonathan Davies will miss the rest of the autumn international series with a pectoral injury.De Villiers acknowledged that Wales had plenty of the game but said: "It's important what you do with that possession and we were probably more clinical.
"We are happy with the win but there is hard work before next week's game.
"We said we need to come out and perform, at least we were able to score three tries tonight."
He added: "It's always physical: Wales are a quality side, it's always tough playing them. Always special.
"These boys had a fantastic summer with the Lions."