The mounting injury crisis in the Wales camp ahead of the Six Nations has worsened with the news that Ryan Jones faces four weeks out.
The flanker dislocated his thumb during Ospreys' Heineken Cup draw against Leicester on Sunday.
Interim head coach Rob Howley is due to name his Six Nations squad on Tuesday, but his options have been restricted by injuries to Alun-Wyn Jones, Luke Charteris, Bradley Davies, Ian Evans and now Ryan Jones.
The Ospreys forward will have his injury further assessed next week, but the indications are that he will miss the Six Nations fixtures against Ireland and France.
Alun-Wyn Jones could be out until early March following shoulder surgery, while Perpignan forward Charteris is out for the season with knee ligament damage.
Cardiff Blues lock Davies will have an ankle operation later this week, Evans has been sidelined since the autumn internationals with a knee problem, and flanker Dan Lydiate has yet to return from an ankle ligament injury.
Australia-born lock James King and uncapped Ospreys team-mate Lloyd Peers are in line for call-ups, while Howley could even consider a recall 36-year-old Ian Gough.
Ospreys hooker Richard Hibbard is another doubt after he appeared to aggravate a shoulder problem against Leicester, while backs Rhys Priestland and Ashley Beck are also out injured.