Ireland captain Paul O'Connell is recovering well from his chest infection and is expected to return to full training on Thursday.
O'Connell was a late withdrawal from the Ireland team ahead of last Sunday's Six Nations opener against Scotland.
The Munster lock sat out training on Tuesday but has responded well to antibiotics and Ireland team manager Mick Kearney is confident he will recover in time to face Wales at the Aviva Stadium on Saturday.
"Paul didn't participate in today's training but hopefully he will be able to do so fully on Thursday," said Kearney.
"We're pretty confident he'll make a full recovery (in time for the Wales game). He's been out in the fresh air for the past two days."
Rob Kearney also sat out training on Tuesday after taking a knock to his calf during the 28-6 win over Scotland, while Cian Healy didn't take part in the running but participated in the scrum session.
Both players should feature against Wales but Leinster team-mates Eoin Reddan and Luke Fitzgerald have been ruled out with calf and abdominal injuries respectively.
Neither player will feature for Leinster this weekend but could return in the Pro12 fixture with the Dragons on 14 February.
Ulster wing Tommy Bowe and Munster forward Donnacha Ryan are also expected to make their comebacks from injury on the same weekend, which could put them in contention for Ireland's trip to Twickenham on 22 February.