Sean Maitland will make his Scotland debut in Saturday's Calcutta Cup clash against England at Twickenham.
The New Zealand-born wing's inclusion is one of six changes made by interim head coach Scott Johnson from the team that lost at home to Tonga in November.
Maitland's Glasgow team-mate Dougie Hall will make his first start in six years, while No 8 Johnny Beattie returns to the line-up for the first time since the World Cup warm-up win over Ireland in 2011.
Sean Lamont switches from the wing to outside centre, Ruaridh Jackson returns at fly-half and Greig Laidlaw starts an international for the first time at scrum-half.
In the front row, Ryan Grant is restored at loose-head after recovering from injury and Euan Murray will become the 33rd Scot to win 50 or more caps, with Jim Hamilton partnering Richie Gray in the second row.
"I've spoken about the importance of this competition, the history and tradition of it, and you couldn't get a more mouth-watering opening than the game between international rugby's oldest foes," said Johnson.
"Selection for us has been about form but also with an eye to the future.
"Sean Maitland is very proud to be pulling on the Scotland jersey for the first time. His family will be rapt because they raised him in New Zealand always reminding him of his Scottish heritage, getting up in the early hours of the morning to watch both the Five and Six Nations games on the TV.
"He's shown he can play footy with the best of them and the impact he's made since arriving at Glasgow in the autumn has underlined what we'd seen of him playing for the Crusaders in Super Rugby."
Kelly Brown captains the side, with Laidlaw and Grant named as vice-captains.
Scotland: Hogg, Maitland, Lamont, Scott, Visser, Jackson, Laidlaw; Grant, Hall, Murray, Gray, Hamilton, Strokosch, Brown, Beattie.
Replacements: Ford, Low, Cross, Kellock, Denton, Pyrgos, Weir, Evans.
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