Second-row Bridget Millar-Mills is to make her debut this Saturday against England in the opening round of the Women's Six Nations.
The lock will be partnered by Lindsay Wheeler, playing in her 53rd Test match. Millar-Mills could also come up against her sister Hariet, who is on the England bench.
The pack includes experienced prop Heather Lockhart, winning her 59th cap. Joining her in the front-row is hooker Sarah Quick and tighthead Tracey Balmer.
In the back row, influential captain Susie Brown is flanked by Tess Forsberg and Mary Lafaiki, who is making her first start.
Winger Annabel Sergeant returns to the starting XV after a year with the Scotland Sevens. Sergeant is joined in the back three by Megan Gaffney on the other wing and Steph Johnston at full-back.
Sarah Dixon is set to partner Lisa Ritchie in the centres. Louise Dalgliesh and Tanya Griffith complete the starting line-up as the half-backs for the Scots.
The bench sees the addition of new faces, Becca Parker, Jade Konkel, Sarah Law and Leanne Neary.
Head coach Karen Findlay said: "Scotland against England always has that added edge and it'll be a really good opportunity to see how our training has progressed, how our squad has developed and will be an exciting start to the 2013 campaign.
Scotland: 15 Steph Johnston, 14 Annabel Sergeant, 13 Sarah Dixon, 12 Lisa Ritchie, 11 Megan Gaffney, 10 Tanya Griffith, 9 Louise Dalgliesh 1 Heather Lockhart, 2 Sarah Quick, 3 Tracey Balmer, 4 Lindsay Wheeler, 5 Bridget Millar-Mills, 6 Mary Lafaiki, 7 Tess Forsberg, 8 Susie Brown (captain)
Replacements: 16 Beth Dickens, 17 Suzanne McKerlie-Hex, 18 Lindsey Smith, 19 Becca Parker, 20 Jade Konkel, 21 Sarah Law, 22 Leanne Neary, 23 Lauren Harris