Marland Yarde will make his England debut on Saturday as England aim to complete a clean sweep over Argentina.
The London Irish wing has been included in a three-quarter line also featuring Bath centre Kyle Eastmond, who starts an international for the first time.
The rugby league convert benefits from Billy Twelvetrees' Lions call-up, while Yarde replaces David Strettle on the left.
The tourist's backs this weekend have just 34 caps between them and have the youngest average age of any England back division since 1999.
Head coach Stuart Lancaster said: "It has definitely got an X-factor to it, the back line.
"Marland has shown in training and in the games that he is ready for this chance. If you look at the stats at the end of the season and compared all the wingers and back three players, he is right up there in terms of defenders beaten, metres made and line breaks.
"Eastmond replacing Twelvetrees is as close to a straight swap as there can be. They are different physically but Kyle can definitely carry and he can distribute and pass pretty much like Billy can.
"The timing of his passing, the range of passing he has got is exceptional and the challenge is to translate that into a game.
"The way we want to play should allow him to express himself and show those talents in the game and it is the next step for him to prove he can do it."
England won the first Test 32-3 on the back of a dominant forward display, and Lancaster reckons it will again be down to the pack to create a platform for the backs to perform.
He said: "There's definitely going to be a reaction from Argentina and what laid the foundation for our performance last week was our set-piece.
"You only get to see the talent to shine through if you get your fundamentals right: the physicality, the contact area, the defence and the set-piece.
"We will also have to deal with what I am sure will be a highly motivated Argentina side."
England: 15 Brown; 14 May, 13 Joseph, 12 Eastmond, 11 Yarde; 10 Burns, 9 Dickson; 1 Marler, 2 Webber, 3 Wilson, 4 Launchbury, 5 Attwood, 6 Wood (c), 7 Kvesic , 8 Morgan.
Replacements: 16 Paice, 17 Thomas, 18 Doran-Jones, 19 Lawes, 20 Vunipola, 21 Wigglesworth, 22 Myler, 23 Foden.