England Women's head coach Gary Street has made seven changes to the team who beat Scotland 76-0 last weekend.
There is a new look front row with Rochelle Clark, Victoria Fleetwood and Sophie Hemming all starting this weekend's Six Nations clash with Ireland.
Rowena Burnfield comes in at lock to partner Tamara Taylor in the second row. Street has opted for an unchanged back row.
In the backs Kay Wilson switches from wing to fullback. Wilson is joined in the back three by the returning Sally Tuson and Francesca Mathews.
The final change sees LaToya Mason coming in at scum-half and being named vice-captain.
Street said: "As always I want to rotate the squad and give players game time. We have brought in some real experience in the front row for Saturday's game in Rochelle Clark and Sophie Hemming - who share 120 caps between them - whilst Sally Tuson has forced her way into the starting line-up with her powerful and try scoring efforts against Scotland.
"I am also pleased to welcome back Fran Matthews who had a superb autumn international series and is looking to get some game time under her belt.
"Ireland always raise their game against us so we know this is going to be one of our toughest games of the tournament. It is certainly up there as one of the big games of the championship.
"That said we will be treating it as just another game, our win over Scotland has given the whole squad a real confidence boost and hopefully if we meet our own expectations then the result will take care of itself."
England Women: Kay Wilson, Francesca Matthews, Abigail Chamberlain, Amber Reed, Sally Tuson, Ceri Large, LaToya Mason, Rochelle Clarke, Victoria Fleetwood, Sophie Hemming, Rowena Burnfield, Tamara Taylor, Joanna McGilchrist, Hannah Gallagher, Sarah Hunter.
Replacements: Emma Croker, Laura Keates, Roz Crowley, Rebecca Essex, Harriet Millar-Mills, Georgina Gulliver, Lauren Cattell, Fiona Pocock