Toby Flood has been ruled out of England's autumn international against New Zealand with a toe injury.
The Leicester fly-half was withdrawn at the weekend in England's 16-15 defeat to South Africa after suffering ligament damage in the big toe of his right foot.
Owen Farrell replaced Flood at Twickenham and is set come in at fly-half on Saturday against the All Blacks, while the uncapped Freddie Burns is likely to be named on the bench.
England coach Stuart Lancaster told Sky Sports News: "It's a big blow to lose Toby. He's our most experienced player and against the All Blacks you want as many caps on the deck as you can get really.
"But there's an excitement about bringing Freddie Burns in. He is one of the form players in the Premiership, if not the form player.
"He has trained with us over the last couple of weeks so he comes in with a knowledge of what we are doing. What we need to do now is just to bring him up to speed ready for Saturday."
Lancaster was non-committal when asked if Burns may even be preferred to Farrell against the All Blacks.
He said: "What I am excited about is two great young English players going toe to toe with each other and trying to do their best for England. It's a good position to be in as a coach and I'm excited to be working with both of them this week."
Lancaster is optimistic Alex Corbisiero will be fit to face New Zealand, although the loosehead prop will not train until Thursday.
Corbisiero was impressive on his international comeback against South Africa, but it was only his third game in five months after recovering from a knee injury and the England medics are being cautious.
What will the outcome be?
New Zealand win