New Argentina coach Daniel Hourcade has made five changes to the team for Saturday's clash with England at Twickenham.
Hourcade - who has replaced Santiago Phelan as Pumas boss - makes three switches in the backs and two in the pack from the team which started their last match, a humiliating 54-17 defeat to Australia.
Maximiliano Bustos comes into the front row for injured prop Juan Figallo while a last-minute change in the match squad means Eusebio Guinazu retains his place in the team as hooker because Worcester's Agustin Creevy withdrew due to injury.
Juan Manuel Leguizamon will lead the side because regular captain Juan Fernandez Lobbe is out for three months with a fractured elbow.
Argentina's outstanding young flanker Pablo Matera - who has signed a short-term deal with Leicester - moves from openside to blindside flanker.
Lucas Gonzalez Amorosino comes into the team at full-back in place of the injured Juan Martin Hernandez and Santiago Fernandez comes in at inside centre for Felipe Contepomi, who retired after the defeat to Australia.
Tomas Cubelli has been preferred to Martin Landajo at scrum-half in a switch between two players who play their club rugby in the amateur Buenos Aires club championship - all the other 13 starters play in the Top 14 or Aviva Premiership.
Experienced centre Gonzalo Tiesi and uncapped teenage wing Santiago Cordero and young hooker Santiago Iglesias, both of whom were not in the Pumas squad during the Rugby Championship, have been brought on to the bench.
Despite the missing starts, it is still a hugely experienced team, with the likes of Leicester prop Marcos Ayerza and Toulouse lock Patricio Albacete world-class campaigners.
The starting XV has 417 caps, 204 than the team England fielded against Australia last weekend.
Argentina continue their tour against Wales in Cardiff on November 16 and Italy in Rome a week later.
Team: 15-L Amorosino; 14-H Agulla, 13-M Bosch, 12-S Fernandez, 11-J Imhoff; 10-N Sanchez, 9-T Cubelli; 1-M Ayerza, 2-E Guinazu, 3-M Bustos, 4-M Galarza, 5-P Albacete, 6-P Matera, 7-J Cabello, 8-JM Leguizamon
Replacements: 16-SI Valdez, 17-N Lobo, 18-JP Orlandi, 19-M Carizza, 20-B Macome, 21-M Landajo, 22-G Tiesi, 23-S Cordero