Australia second row James Horwill will miss the end-of-year tour with a foot injury.
The 23-year-old has been suffering from pain in his left foot since the Wallabies' 16-9 win over South Africa at Perth in July.
And although Horwill has been able to play on, an investigation of the recurrent pain has revealed a tear of the ligament which requires surgery to correct.
"Unfortunately the verdict of the specialist was that James is going to require surgery immediately to get the ligament repaired," said Wallabies coach Robbie Deans.
"And that means having to forgo the opportunity to participate on our tour."
Horwill is facing upto six months on the sidelines with rehabilitation, meaning that he is unable to return for the Reds until possibly the midway point of the 2009 Super 14.
"It's disappointing news, but playing on wasn't an option," said Deans.
"The injury had been given plenty of opportunity to settle but hasn't. In that circumstance, there really wasn't any choice but to get the operation done, and get it done now."
Deans has yet to announce a replacement for Horwill for the tour, with the Wallabies due to play New Zealand, Italy, England, France and Wales.