Toby Flood is expected to be omitted from England's Elite Player Squad on Thursday which could spell the end of the 28-year-old's international career.
Bath fly-half George Ford, a former team-mate at Leicester, is expected to replace Flood in Stuart Lancaster's revised RBS 6 Nations squad.
Flood is primed for a summer move to French Top 14 giants Toulouse and England coach Lancaster is determined to uphold his policy of not selecting overseas-based players by promoting 20-year-old Ford.
Leicester director of rugby Richard Cockerill expects 60-cap playmaker Flood to miss out.
"We've had discussions about it. It looks like that might be the case, that Toby may not be included, but we'll have to wait and see," Cockerill said.
"Toby and Stuart Lancaster have had those discussions and you could intimate that if Toby is left out, that he is moving to France. I would be upset if he left us and went to an English club.
"He could still pick Toby but Stuart always looks to the future and, if Toby is not going to be in the country, it probably makes sense to look to the future."
England boss Lancaster will be forced into a raft of EPS changes to account for a hefty injury list.
Alex Corbisiero, Tom Croft, Geoff Parling, Ben Foden, Manu Tuilagi, Christian Wade and Marland Yarde are all expected to miss the entire 6 Nations.
Bath flyer Anthony Watson, Leicester's fit-again Miles Benjamin and Gloucester's Jonny May have been touted as potential wing replacements for the absent Wade and Yarde.
Flood made his England debut in 2006, progressing to the Rugby World Cup 2007 squad as an injury replacement for his then Newcastle team-mate Jamie Noon.
The Frimley-born pivot appeared as a replacement in England's quarter-final, semi-final and final clashes, as Brian Ashton's side succumbed to narrow defeat to South Africa.
A product of the same Newcastle academy that produced Jonny Wilkinson, Noon and Mathew Tait, Flood made 76 Falcons appearances between 2004 and 2008.
He has clocked up 107 Tigers appearances in five years and is the current Leicester captain but Gloucester's Freddie Burns is set to be brought into Welford Road next season as Flood's replacement.
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