Tom Heathcote will win his third Scotland cap in Saturday's final Quadrangular Tournament game against Italy in Pretoria.
The Bath fly-half replaces Ruaridh Jackson after he failed to recover from the shoulder injury he sustained in last weekend's defeat to South Africa, and is one of three changes for the Scots.
Alastair Kellock starts in the second row in place of Jim Hamilton, who has returned home for the birth of his second child, while David Denton replaces the injured Ryan Wilson in the back row.
Grant Gilchrist, Rob Harley and Tim Visser are all included among the replacements.
Scotland head coach Scott Johnson said: "This is the end of a long season for both the northern hemisphere teams in this tournament and, as I've said before, we want no rocks under our beach towels after Saturday's game.
"When we gathered in camp in Perthshire last month I said that this tour would be about broadening our base and that we'd find out about whether certain players were ready to play international rugby.
"That has happened and we'll take a lot from that but we also want to end the tournament on a high against an Italian team that we know well and that we respect greatly."
Scotland: 15 Peter Murchie, 14 Tommy Seymour, 13 Alex Dunbar, 12 Matt Scott, 11 Sean Lamont, 10 Tom Heathcote, 9 Greig Laidlaw (c); 1 Alasdair Dickinson, 2 Scott Lawson, 3 Euan Murray, 4 Tim Swinson, 5 Alastair Kellock, 6 David Denton, 7 Alasdair Strokosch, 8 Johnnie Beattie.
Replacements: 16 Fraser Brown, 17 Moray Low, 18 Jon Welsh, 19 Grant Gilchrist, 20 Robert Harley, 21 Henry Pyrgos, 22 Duncan Taylor, 23 Tim Visser.