The eight players who warmed the bench for England against Ireland in Dublin on Sunday will all be available for club duty this weekend.
They are Danny Care, Toby Flood, Dylan Hartley, Courtney Lawes, Manu Tuilagi, Mako Vunipola, Thomas Waldrom and David Wilson who started the game against Ireland as replacements but will now leave the England camp on Wednesday.
The eight are now free to turn out for their clubs in the next round of Aviva Premiership matches this Saturday and Sunday.
The rest of the England squad will be joined by Freddie Burns, Alex Corbisiero and Ben Morgan who are rehabilitating injuries.
The Six Nations reconvenes on Saturday, February 23, when England welcome France to Twickenham for their early evening fixture.