Ireland have selected Craig Gilroy on the wing for Saturday's clash with Argentina at the Aviva Stadium.
The 21-year-old notched three tries in last weekend's non-cap 53-0 victory over Fiji at Thomond Park - and will make his official international bow against the Pumas.
Gilroy replaces Ulster colleague Andrew Trimble, who is discarded from Declan Kidney's match-day squad in the only change to the side that were edged 16-12 by South Africa in their Guinness Series opener.
Kidney is battling a long list of big-name injury victims, with the likes of Brian O'Driscoll, Paul O'Connell, Rory Best, Stephen Ferris, Sean O'Brien and Rob Kearney all sidelined.
The game takes on extra significance in deciding which of the two sides will secure a place in the top eight of the IRB rankings, which are being used to determine seedings for the 2015 World Cup.
Ireland are on a run of five Test defeats - their worst run for 14 years - and scrutiny will intensify on Kidney's position as head coach should they fail to produce a positive result.
Argentina, meanwhile, welcome back star full-back Juan Martin Hernandez after he shook off a thigh strain to displace Lucas Amorosino.
Exeter wing Gonzalo Camacho and Montpellier centre Santiago Fernandez come in for Horacio Agulla and Gonzalo Tiesi, while Marcelo Bosch shifts to outside centre.
Ireland: Zebo, Bowe, Earls, D'Arcy, Gilroy, Sexton, Murray; Healy, Strauss, Ross, Ryan, McCarthy, O'Mahony, Henry, Heaslip.
Replacements: Cronin, Kilcoyne, Bent, O'Callaghan, Henderson, Reddan, O'Gara, McFadden.
Argentina: Hernandez, Camacho, Bosch, Fernandez, Imhoff, Sanchez, Landajo; Ayerza, Guinazu, Bustos, Carizza, Cabello, Fernandez, Lobbe (capt), Leguizamon, Senatore.
Replacements: Creevy, Lobo, Gomez Kodela, Vallejos, Leonardi, Vergallo, Tiesi, Montero.
Who will win Saturday's match between Ireland and Argentina?