Sale will play their homes games at the AJ Bell Stadium at 2pm on Saturdays from next season.
The Sharks have played home matches on Friday evenings since 2002 but have decided a schedule change was necessary after falling attendances.
Co-owner Brian Kennedy said: "With the move to the new stadium in 2012, the attendances have dropped off despite the team playing winning rugby this season.
"We have taken on board the feedback from our supporters and the main reason for non-attendance would appear to be transport problems that accompany Friday evening games.
"We have played two Saturday afternoon games in 2014 and our supporters tell us that they have a more relaxed journey to the stadium and enjoy their experience better."
Gordon McKie, chairman of Sale Sharks, added: "Saturday afternoon kick off times will allow us to reach out to a much bigger potential audience across the wider community and schools."