Wales lock Luke Charteris has been ruled out of Sunday's Six Nations clash with England at Twickenham because of a neck injury.
Jake Ball, who made his debut in Wales' victory over France, will take his place in the starting line-up.
"Luke had a bit of a stinger with his neck on Wednesday in a scrummaging session," assistant coach Howley said.
"He has come in today a little bit sore and we have taken the decision early to omit him.
"It is a great opportunity for Jake. I thought he was outstanding in the nuts and bolts of his game against France. He came through with flying colours."
Ball was handed his first start against the French because of an injury to Alun Wyn Jones. Jones is fit to take his place in the line-up this weekend and he will partner the rising Scarlets star who will be playing against the county of his birth.
The 22-year-old was born in Ascot though he emigrated to Australia as a young boy.
England coach Stuart Lancaster recently admitted he may have missed a trick in not being aware of Ball's background.
The Dragons' Andrew Coombs takes Ball's place on the bench.
Team: 15 Halfpenny, 14 Cuthbert, 13 Davies, 12 Roberts, 11 North, 10 Priestland, 9 Webb, 1 Jenkins, 2 Hibbard, 3 A Jones, 4 A Wyn Jones, 5 J Ball, 6 Lydiate, 7 Warburton, 8 Faletau
Replacements: 16 Owens, 17 James, 18 R Jones, 19 Coombs, 20 Tipuric, 21 Phillips, 22 Biggar, 23 L Williams