Wales centre Scott Williams has been ruled out for the remainder of the Six Nations with a shoulder injury.
The 23-year-old, who signed a new contract with Scarlets last week, was injured during the 26-3 defeat to Ireland in Dublin on Saturday.
Williams damaged his right shoulder in a first-half tackle on opposite number Brian O'Driscoll and was forced to leave the field at the Aviva Stadium.
He has since undergone a number of medical tests and it has now been decided that he requires surgery which could rule him out for up to three months.
Williams' injury could leave Wales short of options at outside centre ahead of the clash with France next Friday as Jonathan Davies is still struggling for fitness as he recovers from a torn pectoral muscle.
Wales coach Warren Gatland said: "We are not too sure at the moment whether Jonathan will be available against France. He is still not 100 per cent.
"He played that game for the Scarlets last week and felt a little bit sore, so we are trying to assess him to get up to speed in terms of lifting weights and contact.
"He is not there at the moment, so he is not available at the moment."
George North moved inside to centre during the Ireland game with Liam Williams introduced on the wing, and that could again be the solution Gatland opts for against France.
Scarlets scrum-half Rhodri Williams has also been released from the squad along with another 10 players who are set to feature for their regions this weekend.