James Gaskell and Henry Thomas will both leave Sale Sharks at the end of the current season.
Back-row Gaskell and tighthead Thomas was two of the Sharks' best players, and the news is major blow for the club.
Gaskell has been linked with a move to Wasps, whilst Thomas is expected to join Bath.
Director of Rugby Steve Diamond remains philosophical about their departure.
"'Jamma' and Henry are moving on at the end of the season and replacements are being sought as we speak," he told the club's website.
"We're confident that we'll replace the lads and we wish them all the best. It's the nature of the beast that while some players want to stay, others wish to move on.
"With both Henry and Jamma it's not a money issue as to why they are moving on - it's purely for rugby/lifestyle reasons. There's no rancor or bad feeling and we'll wish both of the lads good luck when they do move on.
"We're looking for a top class scrum-half to replace Dwayne Peel and now a top class tighthead prop to replace Henry, and we're looking worldwide for the right players. Hopefully, we'll get some deals done within the next two or three weeks as we are down the line with one or two."