London Wasps ran in a remarkable 14 tries as they inflicted a club record 90-17 victory over Aironi in Pool Four of the Amlin Challenge Cup.
Dai Young's side showed a ruthless streak at Stadio Pierluigi Zaffanella that included hat-tricks for both William Helu and Guy Thompson.
Wasps led 56-3 at half-time, Helu kicking off the rout in the 10th minute after Aironi's Daniel Yakopo was sin-binned.
The visitors' scrum then claimed a penalty try followed by a Kearnan Myall score three minutes later.
Thompson notched his first on 23 minutes and Thomas Bell followed before Helu crossed twice in the space of three minutes.
Simon McIntyre touched down for Wasps' eighth try of the half, while the hosts mustered a response through Andrea Barbieri before half-time.
Flanker Thompson then completed his hat-trick seven minutes into the second half, while a brace of tries by Jack Winter-Moates saw Wasps surpass their previous highest tally in Europe - 77 points against Toulouse back in 1997.
Charlie Hayter and Joe Simpson then rounded off an historic win with further tries in the final 13 minutes, Joe Carlisle converting 10 of the scores.
Newcastle narrowly escaped defeat on their return to European rugby when they edged out Bucharest 13-12 in Pool Three.
The Romanians led 12-10 at the break and it was not until full-back Tom
Catterick kicked a winning penalty four minutes from the end that Falcons boss Dean Richards could breathe easy.
Newcastle, who saw 10 changes to their side, lost captain Alex Crockett to injury, and Adam Powell crosses before the interval to narrow the early deficit.
The second-half comeback failed to materialise though, but while Joel Hodgson missed the chance to put them in front when his penalty struck an upright, Catterick made no mistake.
Worcester remain winless this season after they were held to a 9-9 draw with Oyonnax despite three first-half penalties from Paul Warwick.
The Warriors looked on course to pick up the points until Conrad Barnard slotted over a last minute penalty for the French minnows.
Meanwhile, George Ford kicked five penalties to give Bath a 15-6 victory at Top 14 side Bordeaux-Begles.