England head coach Stuart Lancaster has received a triple injury boost ahead of the RBS Six Nations decider with Wales at the Millennium Stadium on Saturday.
Tom Croft returns from a serious neck injury to start at blindside flanker, while Owen Farrell gets the nod at fly-half and Wasps lock Launchbury has been passed fit after overcoming an elbow injury.
Croft is set to make only his seventh appearance since returning to action after recovering from a broken neck that almost paralysed him, with the Leicester forward replacing James Haskell.
Launchbury injured his elbow in the 18-11 victory over Italy at Twickenham on Sunday but he passed a fitness test.
Saracens fly-half Farrell limped off in the win over France and missed last weekend's game against Italy with a thigh strain but he has been preferred at No 10 to Toby Flood, who drops to the bench.
Ben Youngs gets the nod at scrum-half ahead of Danny Care, while Harlequins loosehead Joe Marler is the fourth change in personnel as he comes in for Mako Vunipola.
Wales must win by eight points to be certain of retaining their Six Nations crown, while England will secure the Grand Slam if they can claim victory.
"We have come a long way through the QBE (autumn) series and the Six Nations and we want to finish well on what will be a fantastic occasion in Cardiff," said England head coach Stuart Lancaster.
"It will be a great experience for our English team. Every single player, whether they are in the 23 or not this Saturday, has contributed to getting us in this position and they should be proud of that.
"The support of the country has been great throughout the tournament and I am sure they will be right behind us come 5 o'clock."
England: Goode, Ashton, Tuilagi, Barritt, Brown, Farrell, B Youngs; Marler, T Youngs, Cole, Launchbury, Parling, Croft, Robshaw, Wood. Replacements: Hartley, Wilson, Vunipola, Lawes, Haskell, Care, Flood, Twelvetrees.