Defending champions England Under-20s will kick-off their Six Nations campaign on Friday when they take on Scotland in Plymouth.
Head coach Rob Hunter has named four new caps in his starting XV for the clash, which will be shown live on Sky Sports.
Ben Howard, Harry Sloan, Ross Moriarty and Joel Conlon are all set to make their debuts - while entire bench are in line for their first appearances.
Harlequins No 8 Jack Clifford has been handed the captaincy of the side that also includes the likes of Kyle Sinckler, Sam Hill, Anthony Watson and Luke Cowan-Dickie.
Scotland head coach Sean Lineen has named Jonny Gray as captain for opening encounter of the new campaign.
Glasgow Warriors lock Gray, the younger brother of senior international and Sale second row Richie, leads a new-look line-up.
Elite development players Rory Hughes (Scotland Sevens), Sam Hidalgo-Clyne (Edinburgh) and Adam Ashe (Glasgow Warriors) are among those included in the starting line-up.
England Under-20s: 15 Anthony Watson, 14 Jack Arnott, 13 Harry Sloan, 12 Sam Hill, 11 Ben Howard, 10 Henry Slade, 9 Alex Day, 1 Luke Cowan-Dickie, 2 Max Crumpton, 3 Kyle Sinckler, 4 Elliott Stooke, 5 Dom Barrow, 6 Ross Moriarty, 7 Joel Conlon, 8 Jack Clifford (c).
Replacements: 16 Danny Herriott, 17 Danny Hobbs-Awoyemi, 18 Scott Wilson, 19 Tom Jubb, 20 Gus Jones, 21 Nathan Fowles, 22 Will Hooley, 23 Mark Jennings.
Scotland Under-20s: 15 Keith Buchan, 14 Damian Hoyland, 13 Chris Auld, 12 Mark Bennett, 11 Rory Hughes, 10 Tommy Allan, 9 Sam Hidalgo-Clyne, 1 Jamie Bhatti, 2 Russell Anderson, 3 D'arcy Rae, 4 Jonny Gray (c), 5 Adam Sinclair, 6 Ruaridh Leishman, 7 Will Bordill, 8 Adam Ashe.
Replacements: 16 Calum Black, 17 Shawn Muir, 18 Phil Cringle, 19 Cameron Turner, 20 Tommy Spinks, 21 Ali Price, 22 Alex Hagart, 23 Robbie Fergusson.
What they said...
England head coach Rob Hunter
"We're all very excited about getting the competition underway, the lads have worked hard and we're looking forward to see them perform in the white jersey.
"It's great to have some local boys playing at Plymouth, I'm sure that they can't wait to get out there. We know that Scotland are well coached, well organised and highly motivated and it'll be a tough game."
Scotland head coach Sean Lineen
"It's been a really exciting process working with a group of young players who are willing to learn and who want to do something special in this year's Six Nations and IRB Junior World Championship.
"We've had four camps and every single player has worked hard, so we're going down there to give an outstanding performance and there are players who have missed out this time around who are very disappointed.
"However, I've been really impressed with the coaching group and the players. We're really looking forward, with huge anticipation to Friday, so we can see what we can do and hopefully surprise people. England are always a very good team and they will be a good measure of where we are."
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