Leicester hooker Tom Youngs will make his England Test debut in Saturday's International against Fiji at Twickenham.
Youngs, a converted centre and brother of scrum-half Ben who is named on the bench, will pack down with Harlequins prop Joe Marler and Leicester team-mate Dan Cole in the first of four November internationals.
There are five changes to the starting XV from the final summer Test in South Africa, with in-form Gloucester star Charlie Sharples coming on to the right wing in place of Chris Ashton and Harlequins flyer Ugo Monye takes over from the injured Ben Foden on the left.
Brad Barritt partners Manu Tuilagi in midfield while, as expected, skipper Chris Robshaw returns at openside for James Haskell.
On the bench Wasps lock Joe Launchbury and Saracens prop Mako Vunipola will be hoping to make their England debuts and there is a welcome return to the squad for Northampton flanker Tom Wood who missed most of last season because of injury.
England coach Stuart Lancaster said: "This QBE International series will be a real marker of where we are as a squad.
"We are playing four back-to-back matches in four weeks against the top teams in the world and we are confident we can rise to the challenge.
"The foundations are in place, now it's time for us to execute and deliver. Fiji is a good first Test for us and we can't wait to play back at Twickenham.
"The atmosphere against Ireland back in March was superb and you can't underestimate what it means to the players to have 82,000 people and the nation behind them.
"Congratulations to Tom Youngs, who has made a great transition from centre to hooker in a short period and deserves his chance, as do Joe Launchbury and Mako Vunipola, who we are pleased to be able to include in the squad."
England: 15 Alex Goode, 14 Charlie Sharples, 13 Manu Tuilagi, 12 Brad Barritt, 11 Ugo Monye, 10 Toby Flood, 9 Danny Care, 1 Joe Marler, 2 Tom Youngs, 3 Dan Cole, 4 Tom Palmer, 5 Geoff Parling, 6 Tom Johnson, 7 Chris Robshaw, 8 Thomas Waldrom
Replacements: 16 David Paice, 17 David Wilson, 18 Mako Vunipola, 19 Joe Launchbury, 20 Tom Wood, 21. Ben Youngs, 22 Owen Farrell, 23 Mike Brown
Fiji: 15 Simeli Koniferedi, 14 Samu Wara, 13 Vereniki Goneva, 12 Sireli Naqelevuki, 11 Watisoni Votu, 10 Metuisela Talebula, 9 Nicola Matawalu, 1 Ratu Makutu, 2 Viliame Veikoso, 3 Deacon Manu, 4 Leone Nakawara 5 Apisolame Ratuniyarawa, 6 Api Naikatani, 7 Malaki Ravulo, 8 Akapusi Qera
Replacements: 16 Seremaia Naureure, 17 Setafano Samoca, 18 Manasa Saulo 19 Sekonaia Kalou, 20 Iliesa Ratuva, 21 Kelemedi Bola, 22 Josh Matavesi, 23 Ravai Fatiaki