Sale director of rugby Bryan Redpath has been relieved of his position at the Aviva Premiership's bottom club.
Redpath had been in the job for just five months after leaving Gloucester in controversial circumstances at the end of last season.
He has been offered a position as backs coach, which he is understood to be considering.
The club's chief executive Steve Diamond will take charge of the team for the rest of the season, starting with Friday's crucial Premiership clash against fellow strugglers London Irish at the City of Salford Stadium.
Sale have lost all seven of their league games this season - the worst start in the club's Premiership history - and are currently eight points adrift at the bottom of the table.
Redpath took over at Sale in June, signing a four-year deal, after leaving Gloucester.
The appointment of the 41-year-old former scrum-half, who played for the north west club between 2000 and 2005 and was capped 60 times by Scotland, was part of a radical overhaul of Sale over the summer as they left Stockport for the City of Salford Stadium.
Big-name signings including Danny Cipriani and Richie Gray followed, but the positive results have not, with only a single victory this season - a Heineken Cup win over Cardiff Blues.
Diamond will be in charge of team affairs for the rest of the campaign, aided by John Mitchell - the former New Zealand coach who has been acting as a consultant at Sale - and, the chief executive hopes, Redpath.
Asked about the situation as it currently stood, Diamond said: "Effectively, now I will be in charge until the end of the season. John Mitchell will be consulting during that period, and hopefully Bryan Redpath.
"The situation is that after a lot of poor results we have asked Bryan just to take a little bit of time out, a couple of days off to reconsider what we are doing and how we restructure our rugby department.
"We want him to be involved moving forward. He is contracted for a long time after making a big move from Gloucester and we want him to be involved.
"We just need to get the balance of that right, and it clearly isn't right (judging) by our results, so we just want to change it around a little bit to make sure we get the most out of our resources in the coaching - myself, Bryan and John Mitchell."
Will the management changes at Sale lead to an improvement in results?