Saracens prop Mako Vunipola has been called up to England's 32-man squad for the QBE International against Fiji at Twickenham.
England will take on the Pacific Islanders on November 10 - with Vunipola pushing hard for a first cap after an impressive start to the season.
Wasps flanker James Haskell, in-form Harlequins winger Ugo Monye and Leicester hooker Tom Youngs have also been promoted to the elite playing squad from the Saxons after Tom Croft, Ben Foden, Alex Corbisiero and Rob Webber were ruled out through injury.
Monye, a key figure as Quins claimed the Premiership title last season, returns to the international set-up for the first time since 2010 - while Haskell and Youngs both toured with the squad in the summer.
England head coach Stuart Lancaster said: "As a coaching team we can't wait to go into camp and get the guys focused on what will be a massive challenge in the QBE Internationals - Fiji and then the three major Southern Hemisphere teams in successive weeks.
"We have been impressed with some of the rugby we have seen in the Aviva Premiership and Heineken Cup and are looking forward to the players bringing that form to Twickenham.
"It's great to be able to give Mako a chance in the squad. He has come through our age grade sides and made a real impact at Saracens. Likewise Tom Youngs, who was with us on tour in South Africa, and we know what James Haskell and Ugo Monye are capable of if they get their opportunity."
England:Mouritz Botha (Saracens), Dan Cole (Leicester), James Haskell (Wasps), Phil Dowson (Northampton), Dylan Hartley (Northampton), Tom Johnson (Exeter Chiefs), Courtney Lawes (Northampton), Joe Marler (Harlequins), Ben Morgan (Gloucester), Tom Palmer (London Wasps), Geoff Parling (Leicester), Chris Robshaw (Harlequins), Mako Vunipola (Saracens), Thomas Waldrom (Leicester), David Wilson (Bath), Tom Wood (Northampton Saints), Tom Youngs (Leicester), Anthony Allen (Leicester), Chris Ashton (Saracens), Brad Barritt (Saracens), Mike Brown (Harlequins), Danny Care (Harlequins), Lee Dickson (Northampton), Owen Farrell (Saracens), Toby Flood (Leicester), Alex Goode (Saracens), Jonathan Joseph (London Irish), Ugo Monye (Harlequins), Charlie Sharples (Gloucester), Manusamoa Tuilagi (Leicester), Jordan Turner-Hall (Harlequins), Ben Youngs (Leicester)