South Africa pair Willem Alberts and Pat Lambie are doubtful for next week's third and final Test against England in Port Elizabeth.
Both players were injured in the second Test success in Johannesburg and will be assessed in the coming days.
Flanker Alberts, who scored the opening try in the 36-27 win, has a knee problem while full-back Lambie, himself a replacement for the injured Zane Kirchner, has an ankle problem.
Coach Heyneke Meyer will make a decision on Wednesday as to whether the pair are fit enough to play against Stuart Lancaster's team.
"They will be treated by our medical team in the next few days and we will decide by Wednesday, when we name the team, whether they will play or not," explained Meyer.
Another injured player, lock Juandre Kruger, has had a precautionary X-ray and a scan on his neck and been given the all-clear.
Meyer will be forced to make at least one other change with inside centre Frans Steyn due to get married on the day of the game. Steyn has withdrawn from the squad which has now travelled to Port Elizabeth.