Northampton lock Courtney Lawes has become the latest forward to be ruled out of England's summer tour to South Africa due to injury.
The 23-year-old has been out of action since suffering a stress fracture to his shin in the Six Nations defeat to Wales, which capped an injury-hit tournament for the second row, after a knee injury caused him to miss England's opening two fixtures.
Saints coach Jim Mallinder revealed that Lawes, who has 14 caps to his name, will not play a part in Northampton's Aviva Premiership title bid nor England's three-Test trip to face the Springboks.
He said: "We were hoping he might play some part this season but it's looking like he has not quite recovered enough from his shin injury, so it looks like he'll probably not play for the remainder of this season for Saints or for England.
"He is gutted, you want to be involved in the big games, that means semi-finals, if we get there, and finals and, of course, going on England tours.
"He has been a bit unfortunate, but what he has got to do is have a good off-season, make sure his body fully recovers, then train hard for us in pre-season and I am sure actually then he will come back fighting fit."
Lawes' Northampton team-mate Tom Wood had already been ruled out of the trip to South Africa after a recurrence of the foot injury that forced him to miss the Six Nations.
Leicester flanker Tom Croft will also miss out after suffering a neck injury in the Tigers' recent Premiership win at Harlequins.