Exeter will be without centre Sireli Naqelevuki for approximately six weeks after he suffered a broken arm in the 24-19 defeat to Gloucester on Saturday.
The 31-year-old Fiji international has been a key figure in the Chiefs back division this season, playing in seven Premiership games.
However he was replaced by Josh Tatupu on Saturday after suffering the injury.
"He's going to be out for at least four-to-six weeks if it's a regulation break," said Exeter coach Rob Baxter.
"If it's anything worse than that then, that time lengthens.
"Injuries happen in rugby and you've just got to get on with it.
"Obviously you want all your players fit, and Sireli's a great player, I'm not going to run away from that, but one man doesn't make a team. We've just got to move on."