Matt Stevens will pull on an England jersey for the first time since his drugs ban when the Saxons begin their Churchill Cup campaign on Saturday.
The Saracens prop, who won the last of his 32 Test caps in November 2008, was selected in the 24-man Saxons squad on Monday.
And now Stevens has been named to start in his favoured tight-head position for England's second string against the United States.
The 28-year-old will use the game to further his claims for Rugby World Cup selection, having made a successful return to action with Saracens after serving a two-year suspension for cocaine use.
Stevens will be joined in the Saxons line-up by Saracens team-mate Mouritz Botha, a week after they lifted the Aviva Premiership title with victory over Leicester at Twickenham.
With his Saracens and Leicester players now available, Saxons coach Stuart Lancaster has made 11 changes from the team that lost to the Barbarians on Sunday.
Gloucester lock Dave Attwood continues in the second row and Exeter's Tom Johnson starts again in the back row, although he switches to the openside.
Mike Brown retains the full-back jersey and Henry Trinder, who scored England's first try in the 38-32 defeat by the Barbarians, continues at outside centre.
Otherwise it is all change, with Rory Clegg and Mickey Young forming a new half-back partnership and Billy Twelvetrees at inside centre while Topsy Ojo and Miles Benjamin start on the wings.
Up front, Stevens will pack down with Matt Mullan at loose-head and hooker Joe Gray with Attwood and Botha in the second row.
Jordan Crane captains the team from number eight with James Gaskell starting at blindside flanker.
15 Mike Brown, 14 Topsy Ojo, 13 Henry Trinder, 12 Billy Twelvetrees, 11 Miles Benjamin, 10 Rory Clegg, 9 Micky Young, 1 Matt Mullan, 2 Joe Gray, 3 Matt Stevens, 4 Mouritz Botha, 5 David Attwood, 6 James Gaskell, 7 Tom Johnson, 8 Jordan Crane.
Replacements: 16 David Paice, 17 Kieran Brookes, 18 Graham Kitchener, 19 James Gibson, 20 Paul Hodgson, 21 Alex Goode, 22 Charlie Sharples.