Glasgow hooker Fergus Thomson has been ruled out of the World Cup due to the recurrence of a shoulder problem, which required surgery.
Thomson, 27, who has won eight caps and played at the last World Cup four years ago, is likely to be out of action for up to six months.
"As we are at the end of the season Fergus has been seen by specialist surgeon Julie McBirnie at Spire Shawfair Park Hospital in Edinburgh," said Scotland team doctor James Robson.
"He required three separate components in his shoulder to be repaired and, as a result, will not be able to participate in our Rugby World Cup training squad and has been ruled out of consideration for the tournament itself."
Thomson is disappointed by the setback but is concentrating on his rehabilitation.
"I'm gutted at missing out on the chance to compete at the World Cup," he said.
"My focus will be on working hard with the Glasgow physios on my rehab so that I can be back challenging for a place with the Warriors as soon as possible."
Scotland head coach Andy Robinson added: "It's obviously disappointing news for Fergus but we wish him a speedy recovery."
No player is being added to Scotland's World Cup training squad at this stage.
The tournament takes place in New Zealand from September 9 to October 23.