Scotland wing Max Evans has been ruled out of the RBS Six Nations wooden spoon decider with Italy due to an ankle injury.
Evans, who scored a try in Scotland's 22-16 defeat to England last Sunday, was due to start against the Azzurri but has had to be replaced by Nikki Walker.
Head coach Andy Robinson is hoping that Walker can take advantage of the opportunity and help his side avoid finishing bottom of the Six Nations table.
"Our medical team have worked tirelessly as ever but Max is not quite right for the rigours of a Test match," Robinson said.
"We wish him a speedy recovery. Nikki has been part of our squad throughout the championship and played in our last Murrayfield international against Ireland.
"This is a golden opportunity for him now to produce a special performance. We approach tomorrow with confidence and determined to give the Murrayfield crowd a lot to cheer about."
Walker was not originally named on the bench but comes straight into the starting XV, bringing the number of changes from the loss at Twickenham to two.
Geoff Cross has been brought in at tighthead prop in place of Moray Low, who drops out of the 22 completely as Euan Murray is included as a replacement.