Scotland duo Ruaridh Jackson and Chris Paterson are already eyeing a shock win over England to end their Grand Slam dream.
Scotland head to Twickenham on Sunday week aiming to secure their first win in this year's RBS 6 Nations event.
Andy Robinson's side suffered their third straight defeat on Sunday as Ireland recorded a 21-18 victory at Murrayfield.
But fly-half Jackson believes Scotland have an opportunity to avoid a potential wooden spoon decider with Italy on March 19 by inflicting England's first defeat of the tournament.
The 23-year-old said: "It's certainly going to be a tough game and it would be awesome to be a part of.
"They're on a roll, so it will be up to us to cause a shock by going down there to get a win."
Paterson, who won his 102nd cap on Sunday, added: "Although England are three from three, they'll not be thinking about a Grand Slam, they'll just be thinking about Scotland.
"They're playing well, they've got a dangerous attack and a pretty good defence. We'll have to improve if we want to do it."