Schalk Burger and Juan de Jongh have become the latest players to pull out of the South Africa squad to tour Europe.
Both players suffered injuries in Saturday's Currie Cup final - and have now been withdrawn from the squad after scans in Johannesburg on Monday.
Burger has suffered a broken rib, while De Jongh has a hairline fracture on his left ankle - with the duo joining John Smit, Jaque Fourie, Wynand Olivier, Andries Bekker, Fourie du Preez, Heinrich Brüssow, JP Pietersen, Gurthrö Steenkamp, Butch James, BJ Botha and Ricky Januarie on the sidelines.
Adi Jacobs has already been called up as cover for De Jongh, with the uncapped Deon Stegmann replacing Burger.
Bulls full-back Zane Kirchner has also been added to squad as cover to the back division.
"It's a blow to lose players but we've rolled with the punch and already moved on," said Springbok coach Peter de Villiers.
"We trained without them this morning and we already had contingency plans in mind which we've begun to put into operation.
"It's not an ideal situation but we've all got on with our jobs and are focused only on the players that we have in camp."