Gloucester's 29-21 victory over Ulster has come at a cost for Marco Bortolami, with the Italian lock set to be ruled out of action for six weeks with an eye injury.
The former Italy skipper has fractured two bones in his orbital zone - with the experienced forward set to sit out the Six Nations opener against Ireland on February 2 and the visit of England eight days later.
"Bortolami is on his way to Milan to have further check-ups to evaluate if he needs to undergo surgery," said Andrea Cimbrico, Italy Rugby Federation's press officer.
"Due to the delicate position of the fractures, it is expected that he will be out of action between four to six weeks."
Bortolami, who was replaced as skipper by Sergio Parisse, is hopeful of making his return in time to face Wales at the Millennium Stadium on February 23.