Newcastle, Exeter, London Irish, Cardiff and Connacht recorded bonus-point wins in the Challenge Cup.
Aviva Premiership quartet Wasps, Bath, Northampton and Saracens all face daunting away trips in the Champions Cup.
Sam Hidalgo-Clyne played a starring role as Edinburgh beat Bordeaux-Begles 38-20 to reach the Challenge Cup last eight.
Team news for Sunday's European Rugby Challenge Cup Pool 4 meeting of London Welsh and Lyon at the Kassam Stadium.
Gloucester maintained their perfect record in Pool 5 in the European Challenge Cup with a 31-20 victory over Brive.
London Irish hooker David Paice has been banned for three weeks after he was sent off in their clash with Grenoble.
Exeter produced a powerful second-half display to win at Connacht and reach the European Challenge Cup quarter-finals.
Gloucester progressed to the quarter-finals while London Irish and Newport Gwent Dragons also won in the Challenge Cup.
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