Warrington Wolves forward James Laithwaite is out for up to six weeks with a broken foot.
The 22-year-old second rower sustained the injury in last week's victory over Leeds Rhinos, with subsequent scans revealing the extent of the damage.
It comes as a major blow to Warrington ahead of their Tetley's Challenge Cup quarter-final against Bradford Bulls on Sunday.
Regular second rowers Ben Westwood and Trent Waterhouse are still absent through suspension and injury respectively, but head coach Tony Smith revealed Simon Grix could be available after a two-month lay-off.
"The voodoo has struck again. Poor old James has been playing exceptionally well and really coming on but he's out for approximately six weeks," said Smith.
"Hopefully we'll get the all-clear on Simon Grix and we get back a seasoned campaigner that's been very good for us in recent years."
Smith is confident leading try scorer Joel Monaghan will play against the Bulls despite taking a kick to the face while scoring the Wolves' final try against the Rhinos.
"He hasn't trained this week but with a nine-day turn-around I'm pretty confident he'll come through by Sunday," Smith concluded.
Warrington currently sit fifth in the Super League, with nine wins from 15 matches.