St Helens coach Nathan Brown has revealed that Lance Hohaia will be out of action for around eight weeks.
The Saints stand-off suffered a foot injury during the 58-16 victory over London Broncos on Saturday.
Hohaia will miss the remainder of the regular Super League campaign, with just six rounds left of the campaign remaining, it means the New Zealand international's next match is likely to be in the play-offs.
But the blow for Saints is offset by the return of Luke Walsh, who has missed the last three games with a back injury.
The Australian scrum-half is available for selection when St Helens take on Widnes at Langtree Park on Friday.