Wigan captain Sean O'Loughlin is set to be sidelined for another five weeks following a knee operation.
The 30-year-old forward had surgery after pulling out of the England squad for last week's International Origin match against the Exiles.
England medical staff said his recovery from an earlier injury had been slower than expected but Wane revealed O'Loughlin was due to make a relatively quick return from the procedure.
Warriors coach Shaun Wane said: "It's not gone too bad, so he'll be there or thereabouts in about five weeks from now.
"It was a six to eight week operation. You have to look at this as a positive.
"Rugby players have operations, they get knocks, but the plus side for Sean is he'll have two months where his body is going to repair.
"He'll come back a different player for a really important end of the season when we'll need him most."
Wigan have a lengthy injury list with Michael McIlorum, Ben Flower, Gil Dudson
and Blake Green sidelined, while there are doubts over Matty Smith, Darrell
Goulding and Iain Thornley ahead of Monday's trip to Warrington.
Wane had hoped stand-off Green, out since suffering an ankle strain in the
Challenge Cup win over Hull KR six weeks ago, would be fit by now but he remains among the casualties.
"It is one of those sort of injuries where you can't really put a definitive time-frame on it. He can be three, six, eights weeks," Wane added.
"But he is a good pro and has worked hard on his rehab. He'll be back as soon as he can but I think this game is probably a couple of weeks too early."
Wigan should at least welcome back Sam Tomkins, Pat Richards and Liam Farrell from the side which beat Widnes 33-32 a fortnight ago.