Leigh half-back John Duffy has announced his retirement at the age of 32 after failing to recover from a back injury.
Duffy became Super League's youngest debutant when he played for Warrington at the age of 16 in 1997, when he also won his first cap for Scotland against France.
He was named in Scotland coach Dave Rotheram's initial squad for the forthcoming European Cup but has been advised by a specialist to hang up his boots.
Duffy, who also played for Widnes, Salford and Whitehaven, has now secured a coaching role with Leigh.
"It's been an emotional few days," said Duffy. "I'm very sad to miss Scotland's games as they were going to be my swansong.
"I was so proud every time I joined up with Scotland - Steve (McCormack) and Dave have created a great environment which brought out the best in us. I hope the boys can do it without me!"