The Exiles and Huddersfield have been dealt a blow with the news Australian forward Luke O'Donnell is facing an extended spell on the sidelines.
The 30-year-old has been ruled out for four to six weeks after sustaining a hamstring injury in the warm-up to the Giants' match against St Helens at the weekend.
The former Australia Test back-row forward out has already begun an intense period of rehabilitation.
But he will miss the inaugural international Origin fixture between the Exiles and England at Headingley on June 10.
His absence will also be a blow to the Giants ahead of Sunday's Carnegie Challenge Cup fifth-round tie against Catalan Dragons.
However, that disappointment could be offset by the return of prop forward Keith Mason from a knee injury.
Mason, who signed a new contract with the Giants on Tuesday taking him to the end of the 2015 season, was initially ruled out for 12 weeks after damaging his left knee against Wakefield on April 3.
But he had his brace removed last week and will join up with the rest of the squad for full training on Wednesday.
"I'm probably about four or five weeks ahead of schedule," he said.
Huddersfield will also be without centre Joe Wardle for Sunday's cup tie after he sustained a minor hamstring injury in the 40-18 win over St Helens.