Leed Rhinos take on Crusaders in the only all-Super League tie in the fourth round of the Carnegie Challenge Cup.
The Rhinos, last year's beaten finalists whose last cup success was in 1999, will have home advantage against Iestyn Harris' team on the weekend of May 7-8.
"It's a big advantage if you can play in such a big game at home," said Leeds coach Brian McDermott.
"Crusaders are a useful team and they'll be fancying their chances. We're going to get ready for a hard battle."
The other 13 Super League clubs have all been paired with Championship opponents.
Holders Warrington, who have not lost a Challenge Cup tie since May 2008 when they went down 40-34 in the fifth round at St Helens, will begin their defence of the trophy against Championship 1 club Keighley.
With home advantage the Wolves will be overwhelming favourites to extend their winning run, but coach Tony Smith insists he will not be taking the part-timers for granted.
"It's a good draw," said Smith. "It's good to be at home. You don't want to take anybody lightly and we certainly won't.
"Obviously it could have been a lot tougher but you've got to be on your game."
Super League champions Wigan have been drawn at home to Barrow, a tie that will mean a reunion for the Raiders' new coach Nigel Wright, a former Wigan player.
"We're looking forward to it," said Wigan coach Michael Maguire.
"Our players are keen to do well in the competition and we're very happy with a home tie."
Early Championship leaders Leigh will fancy their chances of springing an upset against Catalan Dragons, while the other French club in the last 32, domestic champions Lezignan, face a difficult trip to Featherstone.
There will also be a west Yorkshire derby between Halifax and Bradford.