Aside from Salford's trip to leaders Huddersfield on Sunday, Hull KR have the biggest handicap of the weekend as they take on the Wigan Warriors at the DW Stadium.
They are playing a team who have just recorded a 70-0 Challenge Cup semi-final victory, however +20 for the Robins is good value.
They may have struggled against Warrington two weeks ago - yet they were only 12-6 down at half time - but, prior to that, they have not lost by over 20 points since April.
The Warriors have won their last four home games against Hull KR, yet their last meeting at the DW was by a 14-point margin.
The safe bet for this one is Hull KR on the half-time handicap of +10 at evens.
Only once in their last nine games have they been losing by more than 10 points at half-time - and even that was in a game they went on to win.
Their hopes are boosted also by the fact that goal-kicking winger Pat Richards will be absent from the Wigan squad.
The six foot two Australian has kicked an amazing 84 goals in just 19 appearances this season and has also crossed the whitewash 14 times.
With fellow winger Josh Charnley likely to take over the kicking duties, tries out wide have more chance of being worth four points rather than six, working in the Robins' favour.
On the other hand, Michael Dobson has kicked a huge 70 goals, missing just 22 - a 76 per cent success rate.
This could be where the handicap is won and lost and, with Wigan up against a 20 point margin - and 10 points at half time - it should work in the favour of the Robins.
On Saturday, it's the Saints' turn to cross the channel and take on the out-of-form Catalans Dragons.
St Helens come into the game in good spirits after beating their arch-rivals Wigan in their last appearance and they have a good record in the south of France as well.
Nathan Brown's men have not lost on French soil since March 2008 - winning their last four away trips there.
However, things are not as rosy as they sound for the Saints as they have lost their last two home meetings against the Dragons, including a 12-22 defeat in Round 12 this year.
Long-term absentee Brent Webb remains on the sidelines but, this week, he'll be joined by Scott Dureau and captain Remi Casty.
Every cloud has its silver lining, though, and the Frenchmen are likely to welcome back Thomas Bosc and, former St Helens man, Leon Pryce in the halves.
Pryce has assisted a huge 18 tries for the Catalans this season in just 20 appearances and will give the Dragons the go forward they need on Saturday night.
As Leeds coach Brian McDermott controversially pointed out recently, the volatile Catalans crowd can have an effect on visiting teams so expect the players to respond this week and cover the -2 handicap at 10/11.
"Catalans may be a tough place to go but the Saints have won there on their last four visits so expect the Catalans slump in form to continue.
"The odds are already moving in St.Helens favour so the punters know something too.
"Bradford have won their last three meetings with Wakefield and I'm hoping they turned a corner last time out with a good win over Hull.
"It will be a tight game either way so +6 for Bradford covers me both ways."