Australia travel to St Kitts attempting to open up a 4-0 series lead without Ricky Ponting after the influential skipper has been ruled out with a wrist injury.
Ponting suffered the setback whilst batting in the tourists series-clinching seven-wicket win in Granada and he may also be forced to sit out the final one-day clash on Sunday .
The absence of Ponting will hand David Hussey his ODI debut with vice-captain Michael Clarke stepping up to lead the side.
Hussey's inclusion means that seamer Stuart Clark will be the only member of the Australian squad not to have featured in the series if he does not come into the side.
New look Windies
The West Indies selectors have named three newcomers in their squad as they attempt to avoid five straight defeats against Australia and restore some pride at Warner Park.
Fast bowler Kemar Roach, who played in the one-off Twenty20 international against Australia in Barbados on June 20, has been chosen to replace the injured Jerome Taylor.
Roach, who turned 20 on Monday, took two wickets in the 20-over encounter and his deliveries consistently registered close to the 90 miles per hour mark.
Jamaicans Nikita Miller, a left-arm spinner, and Shawn Findlay, a left-handed batsman, have been named to the senior team for the first time.
The inclusion of Findlay could rest on whether West Indies opt to rest any of Chris Gayle, Ramnaresh Sarwan and Shivnarine Chanderpaul - all of whom have niggling injuries.